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Single-Molecule Studies of Actin Assembly and Disassembly Factors PDF available through Get Fulltext Research

Smith, Benjamin A. Gelles, Jeff Goode, Bruce L.

Published in Methods in Enzymology

The actin cytoskeleton is very dynamic and highly regulated by multiple associated proteins in vivo. Understanding how this system of proteins functions in the processes of actin network assembly and disassembly requires methods to dissect the mechanisms of activity of individual factors and of multiple factors acting in concert. The advent of sing...

Interaction of the New Monofunctional Anticancer Agent Phenanthriplatin With Transporters for Organic Cations PDF available through Get Fulltext Research

Hucke, Anna Park, Ga Young Bauer, Oliver B. Beyer, Georg Köppen, Christina Zeeh, Dorothea Wehe, Christoph A. Sperling, Michael Schröter, Rita Kantauskaitè, Marta ...

Published in Frontiers in Chemistry

Cancer treatment with platinum compounds is an important achievement of modern chemotherapy. However, despite the beneficial effects, the clinical impact of these agents is hampered by the development of drug resistance as well as dose-limiting side effects. The efficacy but also side effects of platinum complexes can be mediated by uptake through ...

Hematopoietic stem cell-specific GFP-expressing transgenic mice generated by genetic excision of a pan-hematopoietic rep... PDF available through Get Fulltext Research

Perez-Cunningham, Jessica Boyer, Scott W Landon, Mark Forsberg, E Camilla

Published in Experimental hematology

Selective labeling of specific cell types by expression of green fluorescent protein (GFP) within the hematopoietic system would have great utility in identifying, localizing, and tracking different cell populations in flow cytometry, microscopy, lineage tracing, and transplantation assays. In this report, we describe the generation and characteriz...

Antimicrobial Peptide LL37 and MAVS Signaling Drive Interferon-β Production by Epidermal Keratinocytes during Skin Injur... PDF available through Get Fulltext Research

Zhang, Ling-Juan Sen, George L Ward, Nicole L Johnston, Andrew Chun, Kimberly Chen, Yifang Adase, Christopher Sanford, James A Gao, Nina Chensee, Melanie ...

Published in Immunity

Type 1 interferons (IFNs) promote inflammation in the skin but the mechanisms responsible for inducing these cytokines are not well understood. We found that IFN-β was abundantly produced by epidermal keratinocytes (KCs) in psoriasis and during wound repair. KC IFN-β production depended on stimulation of mitochondrial antiviral-signaling protein (M...

Response of Vibrio cholerae to Low-Temperature Shifts: CspV Regulation of Type VI Secretion, Biofilm Formation, and Asso... PDF available through Get Fulltext Research

Townsley, Loni Sison Mangus, Marilou P Mehic, Sanjin Yildiz, Fitnat H

Published in Applied and environmental microbiology

Little is known about how human pathogens respond and adapt to ever-changing parameters of natural habitats outside the human host and how environmental adaptation alters dissemination. Vibrio cholerae, the causative agent of the severe diarrheal disease cholera, experiences fluctuations in temperature in its natural aquatic habitats and during the...

tRNAscan-SE On-line: integrating search and context for analysis of transfer RNA genes. PDF available through Get Fulltext Research

Lowe, Todd M Chan, Patricia P

Published in Nucleic acids research

High-throughput genome sequencing continues to grow the need for rapid, accurate genome annotation and tRNA genes constitute the largest family of essential, ever-present non-coding RNA genes. Newly developed tRNAscan-SE 2.0 has advanced the state-of-the-art methodology in tRNA gene detection and functional prediction, captured by rich new content ...

Phosphono Bisbenzguanidines as Irreversible Dipeptidomimetic Inhibitors and Activity-Based Probes of Matriptase-2.

Häußler, Daniela Mangold, Martin Furtmann, Norbert Braune, Annett Blaut, Michael Bajorath, Jürgen Stirnberg, Marit Gütschow, Michael

Published in Chemistry (Weinheim an der Bergstrasse, Germany)

Matriptase-2, a type II transmembrane serine protease, plays a key role in human iron homeostasis. Inhibition of matriptase-2 is considered as an attractive strategy for the treatment of iron-overload diseases, such as hemochromatosis and β-thalassemia. In the present study, synthetic routes to nine dipeptidomimetic inactivators were developed. Fiv...

IGF2BP3 Modulates the Interaction of Invasion-Associated Transcripts with RISC. PDF available through Get Fulltext Research

Ennajdaoui, Hanane Howard, Jonathan M Sterne-Weiler, Timothy Jahanbani, Fereshteh Coyne, Doyle J Uren, Philip J Dargyte, Marija Katzman, Sol Draper, Jolene M Wallace, Andrew ...

Published in Cell reports

Insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3) expression correlates with malignancy, but its role(s) in pathogenesis remains enigmatic. We interrogated the IGF2BP3-RNA interaction network in pancreatic ductal adenocarcinoma (PDAC) cells. Using a combination of genome-wide approaches, we have identified 164 direct mRNA targets of IGF...

Facilitating a culture of responsible and effective sharing of cancer genome data.

Siu, Lillian L Lawler, Mark Haussler, David Knoppers, Bartha Maria Lewin, Jeremy Vis, Daniel J Liao, Rachel G Andre, Fabrice Banks, Ian Barrett, J Carl ...

Published in Nature medicine

Rapid and affordable tumor molecular profiling has led to an explosion of clinical and genomic data poised to enhance the diagnosis, prognostication and treatment of cancer. A critical point has now been reached at which the analysis and storage of annotated clinical and genomic information in unconnected silos will stall the advancement of precisi...

TNF-α modulates genome-wide redistribution of ΔNp63α/TAp73 and NF-κB cREL interactive binding on TP53 and AP-1 motifs to...

Si, H Lu, H Yang, X Mattox, A Jang, M Bian, Y Sano, E Viadiu, H Yan, B Yau, C ...

Published in Oncogene

The Cancer Genome Atlas (TCGA) network study of 12 cancer types (PanCancer 12) revealed frequent mutation of TP53, and amplification and expression of related TP63 isoform ΔNp63 in squamous cancers. Further, aberrant expression of inflammatory genes and TP53/p63/p73 targets were detected in the PanCancer 12 project, reminiscent of gene programs com...

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